What is Tapentadol (Aspadol)?  Tapentadol is an opioid obtained to handle mild to severe discomfort or pain. Tapentadol is a centrally-acting opioid anesthetic approved for the assistance of pain in grown-ups. As well as inhibiting norepinephrine uptake, the Tapentadol dose acts at mu-opioid receptors, although the clinical application of this action is unknown. This drug relates to a...